Murphy T, Waterhouse DF, James S, Casey C, Fitzgerald E, O’Connell E, Watson CJ, Gallagher J, Ledwidge M, McDonald K. (2016)A comparison of HFrEF vs HFpEF’s clinical workload and cost in the first year following hospitalization and enrollment in a disease management program. International Jounal of Cardiology. 2017 In press

Watson CJ, O’Connell E, Gallagher J, O’Reilly J, Tallon E, Baugh J, O’ Connell J, O’Shea D, Ledwidge M, McDonald K. (2016). Influence of diabetes on natriuretic peptide thresholds in screening for Stage B heart failure. Biomarkers. 2016 Sep;21(6):538-43.

Watson CJ, Horgan S, Neary R, Glezeva N, Tea I, Corrigan N, McDonald K, Ledwidge M, Baugh J (2015). Epigenetic therapy for the treatment of hypertension induced cardiac hypertrophy and fibrosis. J Cardiovasc Pharmacology &Therapeutics. 2016 Jan;21(1):127-37.

Glezeva N, Gilmer JF, Watson CJ, Ledwidge M. A Central Role for Monocyte-Platelet Interactions in Heart Failure. J Cardiovasc Pharmacol Ther. 2016 May;21(3):245-61.

Murtagh G, Lyons T, O’Connell E, Ballot J, Geraghty L, Fennelly D, Gullo G, Ledwidge M, Crown J, Gallagher J, Watson CJ, McDonald KM, Walshe JM. Late cardiac effects of chemotherapy in breast cancer survivors treated with adjuvant doxorubicin: 10-year follow-up. Breast Cancer Res Treat. 2016 Apr;15 (3):501-6.

Li L, Watson CJ, Dubourd M, Bruton A, Xu M, Cooke G, Baugh JA. HIF-1-Dependent TGM1 Expression is Associated with Maintenance of Airway Epithelial Junction Proteins. Lung. 2016 Oct;194(5):829-38

Watson CJ, Gallagher J, Ledwidge M, McDonald K: Biomarker Testing and Pre-emptive Therapy in Preventing Heart Failure. Current Cardiovascular Risk reports, 2015: 9(6).

Glezeva N, Gallagher J, Ledwidge M, O’Donoghue J, McDonald K, Chipolombwe J, Watson CJ.   Heart failure in sub-Saharan Africa: review of the aetiology of heart failure and the role of point-of-care biomarker diagnostics. Trop Med Int Health. 2015 May;20(5):581-588.

Horgan S, Watson CJ, Glezeva N, Collier P, Neary R, Tea I, Corrigan N, Ledwidge M, McDonald K, Baugh J. (2015). Serum amyloid P-component prevents cardiac remodelling in hypertensive heart disease. J. Cardiovasc. Transl. Res. 2015 Dec;8(9):554-66.

Ledwidge M, O’Connell E, Gallagher J, Tilson L, Voon V, Bermingham M, Tallon E, Watson CJ, O’Hanlon R, Barry M, McDonald K (2015). Cost-effectiveness of natriuretic peptide based screening and collaborative care: a report from the STOP-HF (St Vincent’s Screening TO Prevent Heart Failure) study. Euro J Heart Fail. 2015 Jul;17(7):672-9.

Watson CJ, Gupta S, O’Connell E, Thum S, Glezeva N, Fendrich J, Gallagher J, Grote-Levi A, Ledwidge M, Grote-Levi L, McDonald K, Thum T (2015). MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure. Eur J Heart Fail. 2015 Apr;17(4):405-15.

Glezeva N, Voon V, Watson CJ, Horgan S, Ledwidge M, McDonald K, Baugh J (2015). Exaggerated inflammation and monocytosis associate with diastolic dysfunction in Heart Failure with Preserved Ejection Fraction: evidence of M2 macrophage activation in disease pathogenesis. J. Card. Fail. Feb 21(2):167-77.

James S, Barton D, O’Connell E, Voon V, Murtagh G, Watson CJ, Murphy T, Prendiville B, Brennan D, Hensey M, O’Neill L, O’Hanlon R, Waterhouse D, Ledwidge M, Gallagher J, McDonald K (2015). Life expectancy for community-based patients with heart failure from time of diagnosis. Int J Cardiol. Jan 15;178:268-74.

Murtagh G, O’Connell J, O’Connell E, Tallon E, Watson CJ, Gallagher J, Baugh J, Patle A, O’Connell L, Griffin J, O’Hanlon R, Voon V, Ledwidge M, O’Shea D, McDonald K. Importance of Risk Factor Management in Diabetic Patients & Reduction in Stage B Heart Failure. QJM 2015 Apr;108(4):307-14

Neary R, Watson CJ, Baugh JA. Epigenetics and the overhealing wound: the role of DNA methylation in fibrosis. Fibrogenesis Tissue Repair. 2015 Oct 1;8:18

Horgan S, Watson CJ, Glezeva N, Baugh J. Murine models of diastolic dysfunction and heart failure with preserved ejection fraction. J Card Fail. 2014 Dec;20(12):984-95

Watson CJ, Phelan D, Collier P, Horgan S, Glezeva N, Cooke G, Xu M, Ledwidge M, McDonald K, Baugh J. (2014). Extracellular matrix sub-types and mechanical stretch impact human cardiac fibroblast responses to transforming growth factor beta. Connective Tissue Research. Jun;55(3):248-56.

 

Dowling D, Corrigan N, Horgan S, Watson CJ, Baugh J, Downey P, McAuliffe FM. Cardiomyopathy in offspring of pregestational diabetic mouse pregnancy. J Diabetes Res. 2014;2014:624939.

Jan A, Dawkins I, Murphy N, Collier P, Baugh J, Ledwidge M, McDonald K, Watson CJ. (2013) Associates of an elevated natriuretic peptide level in stable heart failure patients; implications for targeted management. Scientific World Journal. Dec 25; 2013: 562763.

Watson CJ, Collier P, Tea I, Neary R, Watson J, Robinson C, Phelan D, Ledwidge M, McDonald K, McCann A, Sharaf O, Baugh J. (2013) Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype. Human Molecular Genetics. Apr 15, 15;23(8):2176-88.

Ledwidge M, Gallagher J, Conlon C, Tallon E, O Connell E, Dawkins I, Watson CJ, O’ Hanlon R, Bermingham M, Patle A, Badabhagni M, Murtagh G, Voon V, Tilson L, Barry M, McDonald L, Maurer B, McDonald K. (2013) Natriuretic Peptide–Based Screening and Collaborative Care for Heart Failure. JAMA. Jul 3;310(1).

Glezeva N, Collier P, Ledwidge M, McDonald K, Watson CJ, Baugh J. (2013) Attenuation of monocyte chemotaxis – a novel anti-inflammatory mechanism of action for the cardio-protective hormone B-type Natriuretic Peptide. J Cardiovasc Transl Res. 6(4):545-57.

Cooke G, Govender P, Watson CJ, Armstrong M, O’Dwyer DN, Keane MP, King R, Tynan A, Dunn M, Donnelly S. (2013) Sarcoidosis, Alveolar β-Actin & Pulmonary Fibrosis. QJM. 2013 106(10):897-902.

Phelan D*, Watson CJ*, Martos R, Collier P, Patle A, Dawkins I, Donnelly S, Ledwidge M, Baugh J, McDonald K. (2012) Modest Elevation in BNP in Asymptomatic Hypertensive Patients Reflects Sub-Clinical Cardiac Remodeling, Inflammation and Extracellular Matrix Changes. PLoS One. 7(11). * Denotes joint first author.

Robinson C, Neary R, Levendale A, Watson CJ, Baugh J. (2012) Hypoxia-Induced DNA Hypermethylation in Human Pulmonary Fibroblasts is Associated with Thy-1 Promoter Methylation and the Development of a Pro-fibrotic Phenotype. Respiratory Research. 2012, 31;13(1):74.

Watson CJ, Phelan D, Xu M, Collier P, Neary R, Smolenski A, Ledwidge M, McDonald K, Baugh J. (2012). Mechanical stretch up-regulates the B-type natriuretic peptide system in human cardiac fibroblasts: A possible defense against transforming growth factor-β mediated fibrosis. Fibrogenesis & Tissue Repair. 7;5(1):9.

Collier P*, Watson CJ*, Waterhouse D, Dawkins I, Petle A, Horgan S, Conlon C, O’Hanlon R, Baugh JA, Ledwidge MT, McDonald KM. (2012). Progression of Left Atrial Volume Index in a Population At Risk for Heart Failure: A Sub-Study of the STOP-HF (St. Vincent’s Screening TO Prevent Heart Failure) Trial. Eur J Heart Fail. 14(9):957-64.* Denotes joint first author.

Abulhul E, McDonald K, Martos R, Phelan D, Spiers JP, Hennessy M, Baugh J, Watson CJ, O’Loughlin C, Ledwidge M. (2012). Long-term statin therapy in patients with systolic heart failure and normal cholesterol: effects on elevated serum markers of collagen turnover, inflammation, and B-type natriuretic peptide. Clin Ther. 34(1):91-100.

Robinson C, Watson CJ, Baugh J. Epigenetics within the Matrix: a neo-regulator of fibrotic disease. Epigenetics. 2012, 1;7(9).

Watson CJ, O’Kane H, Maxwell P, Sharaf O, Petak I, Hyland PL, O’Rouke D, McKnight J, Canning P, Williamson K. (2012). Identification of a methylation hotspot in the death receptor Fas/CD95 in bladder cancer. Int J Oncol. 40(3):645-54.

Collier P, Watson CJ, van Es M, Phelan D, McGorrian C, Tolan M, Ledwidge M, McDonald K, Baugh J. (2012). Getting to the heart of cardiac remodelling; how collagen subtypes may contribute to phenotype. J Mol Cell Cardiol. 52(1):148-53.

Collier P*, Watson CJ*, Voon V, Phelan D, Jan A, Mak G, Martos R, Baugh JA, Ledwidge MT, McDonald KM. (2011) Can emerging biomarkers of myocardial remodelling identify asymptomatic hypertensive patients at risk for diastolic dysfunction and diastolic heart failure? Eur J Heart Fail. 13(10):1087-95.* Denotes joint first author.

Watson CJ, Ledwidge M, Phelan P, Collier P, Byrne J, Dunn M, McDonald K, Baugh J. (2011) Proteomic Analysis of Coronary Sinus Serum Reveals LRG as a Novel Biomarker of Ventricular Dysfunction and Heart Failure. Circ Heart Fail. 4(2):188-97.

Watson JA*, Watson CJ*, McCann A, Baugh J. (2010) Epigenetics, the epicentre of the hypoxic response. Epigenetics 5(4):293-6. * Denotes joint first author.

Koo V, Lee A, Sharaf O, Watson CJ, Hamilton P, Williamson K. (2010) pcDNA3.1tdTomato is superior to pDsRed2-N1 for optical fluorescence imaging in the F344/AY-27 rat model of bladder cancer. Mol Imaging Biol. 12(5):509-19

Mak G, Ledwidge M, Watson CJ, Phelan D, Dawkins I, Murphy N, Patle A, Baugh J, McDonald K. (2009) Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone. J Am Coll Cardiol. 54(18):1674-82.

Watson JA, Watson CJ, McCrohan A, Woodfine K, Tosetto M, McDaid J, Gallagher E, Betts D, Baugh J, O’Sullivan J, Watson RWG, McCann A. (2009) Generation of an epigenetic signature by chronic hypoxia in prostate cells. Human Molecular Genetics 18(19):3594-604

McKnight J, Maxwell P, O’Rourke D, Anderson N, Watson CJ, Patterson A, Healy E, Williamson K. (2007) The relationship between cytokeratin expression in bladder washings and resected tumour specimens. Histopathology 50(2):275-8.

O’Kane HF, Watson CJ, Johnston SR, Petak I, Watson RW, Williamson KE. (2006) Targeting death receptors in bladder, prostate and renal cancer. J Urol. 175(2):432-8.

Duggan B, Gray S, McKnight J, Watson CJ, Johnston S, Williamson K. (2004) Oligoclonality in bladder cancer: implication for molecular therapies. J Urol. 171(1):419-25.

Morning Ireland (RTE Radio 1) 12th November 2016

Hear about the BIOTOPE project on World Pneumonia Day

 

 

First ESTHER Ireland Partnerships Forum November 2016

Talk on “From Goppa Codes to Gorey”

 

UCD School of Medicine News November 2015

gHealth Research Receives Grand Challenges Explorations Grant

First ESTHER Ireland Partnerships Forum

Talk on “From Goppa Codes to Gorey”